We're often asked about content authoring best practices. While we don't create content here, we see A LOT of it everyday.
Browsers - For the most part, as long as you have a modern browser, our software will not care what browser the learner uses.
Exit Buttons - Giving the learner a clear exit will help in situations where the wrong window gets closed first. Scenarios where the player window is shut prior to the course window or the course and player window shut at the same time can result in a race condition that may cause the runtime communication to get lost in the shuffle. More information on lost completions here.
Bookmarking - If you have content that may be a bit longer in nature, you will definitely want to make sure your content bookmarks We have seen learners getting pretty salty when taking their OSHA 10 hour training and half way through they leave, then re-enter and have to start from the beginning.
Frameset/Frameset vs. Frameset/New Window - While both options work well, if you are launching in frameset/frameset, you definitely want the course to have an exit button...if you close a frameset/frameset launched course by closing your browser, you would be in danger of losing runtime data as you are closing the player and content at the same time.
Conversely, while we still want you to have an exit button, if you launch the SCO in a new window, you do have less of a chance of that race condition that may come up when you launch frameset/frameset and close abruptly.
Lastly, have your content authors lean on the tutorials and support provided by your authoring tools. We have seen some things, but can only offer high level guidance for specific tools. We don't really create content here, the authoring tool support folks deal with their application every day.
If you have any questions, please send a message to support@rusticisoftware.com