We recently had a client find a number of 404 errors in their IIS logs from when they play a piece of Articulate content. The 404's stem
from a missing file, art_plugins.xml. Once the course is launched, the inability to find said file seems to keep hitting the server and filling up the logs.
Turns out, Articulate has a known problem with a missing file, art_plugins.xml. You can check out this forum for a way around this:
http://www.articulate.com/forums/articulate-presenter/3251-what-where-art_plugins-xml.html